Myelodysplastic Syndrome Overview in the Elderly: Case Report

Authors

  • Devi Harmita Universitas Tanjungpura
  • Wulida Litaqia Tanjungpura University 1, Indonesia
  • Ainun Najib Febrya Rahman Tanjungpura University 1, Indonesia
  • Hanafi Tanjungpura University 1, Indonesia
  • Haryati Septiani Tanjungpura University 1, Indonesia
  • Dikki Saputra Universitas Tanjungpura

DOI:

https://doi.org/10.37680/jcd.v7i1.7056

Keywords:

Elderly, Hematological Disorders, Nursing Assessment of Myelodysplastic Syndrome

Abstract

Background: Myelodysplastic syndrome (MDS) is a hematopoietic disorder characterized by cytopenia, dysplasia, and genetic abnormalities that can transform into acute myeloid leukemia. MDS cases generally occur in children and adults. This case report involves a 75-year-old elderly individual with no history of MDS or family illness. Purpose of the Study: This study serves as a reference for screening the nursing perspective of MDS in the elderly. Methods: This research is a descriptive case report of 1 case. Results: A 75-year-old elderly patient with 1 month of weakness and pallor, blood pressure of 140/90 mmHg with controlled hypertension for 1 year. Laboratory results showed correlation with MDS symptoms: leukopenia (leukocytes 2.85 x 10^3/µl), thrombocytopenia (platelets 1,000/µl), and anemia (Hb 4.3g/dl). Conclusions: Hematological data support the patient experiencing MDS. Additionally, the patient's exposure to pesticides for 40 years also strongly supports the occurrence of MDS as it is a triggering factor for MDS.

References

Avagyan, S., & Shimamura, A. (2022). Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies. Frontiers in Oncology, 12(March). https://doi.org/10.3389/fonc.2022.813149

Avgerinou, C., Giannezi, I., Theodoropoulou, S., Lazaris, V., Kolliopoulou, G., Zikos, P., Alamanos, Y., Leotsinidis, M., & Symeonidis, A. (2017). Occupational, dietary, and other risk factors for myelodysplastic syndromes in Western Greece. Hematology, 22(7), 419–429. https://doi.org/10.1080/10245332.2016.1277006

Bestri Neli Agustin, Hanifah Maani, D. (2019). Gambaran Hematologi Pasien Myelodysplastic Syndrome di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 8(3), 500. https://doi.org/10.25077/jka.v8i3.1033

Bizymi, N., Pitsidianakis, G., Ierodiakonou, D., Stathakis, G., Vasarmidi, E., Hiraki, S., Bolaki, M., Karagiannis, K., Fanaridis, M., Liopyrakis, K., Marinos, L., Xilouri, I., Antoniou, K. M., & Tzanakis, N. (2021). Case Report: Diagnosis of Myelodysplastic Syndrome in a 72-Year-Old Female With Interstitial Lung Disease. Frontiers in Medicine, 8(August), 1–6. https://doi.org/10.3389/fmed.2021.673573

Brunner, A. M., Leitch, H. A., van de Loosdrecht, A. A., & Bonadies, N. (2022). Management of patients with lower-risk myelodysplastic syndromes. Blood Cancer Journal, 12(12), 1–13. https://doi.org/10.1038/s41408-022-00765-8

Crawford, J., Becker, P. S., Armitage, J. O., Blayney, D. W., Chavez, J., Curtin, P., Dinner, S., Fynan, T., Gojo, I., Griffiths, E. A., Hough, S., Kloth, D. D., Kuter, D. J., Lyman, G. H., Mably, M., Mukherjee, S., Patel, S., Perez, L. E., Poust, A., … Pluchino, L. (2017). Myeloid growth factors, version 2.2017. JNCCN Journal of the National Comprehensive Cancer Network, 15(12), 1520–1541. https://doi.org/10.6004/jnccn.2017.0175

Fenaux, P., Platzbecker, U., & Ades, L. (2020). How we manage adults with myelodysplastic syndrome. British journal of haematology, 189(6), 1016-1027.

Garcia-Manero, G., Chien, K. S., & Montalban-Bravo, G. (2020). Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management. American Journal of Hematology, 95(11), 1399–1420. https://doi.org/10.1002/ajh.25950

Hasserjian, R. P. (2018). Myelodysplastic Syndrome Updated. Pathobiology, 1–7. doi:10.1159/000489702

Lauritsen, T. B., Nørgaard, J. M., Dalton, S. O., Grønbæk, K., El-Galaly, T. C., & Østgård, L. S. G. (2023). 10-year nationwide trends in incidence, treatment patterns, and mortality of patients with myelodysplastic syndromes in Denmark. Leukemia Research, 128, 107056. https://doi.org/10.1016/j.leukres.2023.107056

Montoro, J., Gallur, L., Merchán, B., Molero, A., Roldán, E., Martínez-Valle, F., ... & Valcárcel, D. (2018). Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes. Annals of hematology, 97(8), 1349-1356.

Oktariani, S., Handaya, A. Y., & Purwanto, I. (2020). Peningkatan profil klinik-hematologi pada pasien sindrom mielodisplasia multilini paska splenektomi total. Jurnal Penyakit Dalam Udayana, 4(1), 1–4. https://doi.org/10.36216/jpd.v4i1.133

Platzbecker, U. (2019). Treatment of MDS. Blood, blood–2018–10844696. doi:10.1182/blood-2018-10-844696

SITORUS, V. L. M. (2018). Indeks-Indeks Trombosit Darah Tepi Dan Kejadian Myelodysplastic Syndrome. 69.

Wijaya, I. G. H. A. (2022). Myelodysplastic syndromes: Laporan Kasus. Intisari Sains Medis, 13(2), 613–617. https://doi.org/10.15562/ism.v13i2.1383

Downloads

Published

2025-04-30

How to Cite

Harmita, D., Wulida Litaqia, Ainun Najib Febrya Rahman, Hanafi, Haryati Septiani, & Dikki Saputra. (2025). Myelodysplastic Syndrome Overview in the Elderly: Case Report. Journal of Community Development and Disaster Management, 7(1), 403–413. https://doi.org/10.37680/jcd.v7i1.7056